Specific sDMA modifications on the RGG/RG motif of METTL14 regulate its function in AML
The study confirms the coexistence of sDMA and aDMA modifications on METTL14's RGG/RG motifs, with sDMA at R425 and R445 enhancing METTL3:METTL14's catalytic efficacy and regulating gene expression through m6A deposition in cancer cells.
Authors
- Yuyu You
- Yanqiu Yuan (ORCID: https://orcid.org/0000-0001-8360-4843)
- Yang Mao (ORCID: https://orcid.org/0000-0002-9674-1158)
- Rou Zhang (ORCID: https://orcid.org/0009-0001-5056-8345)
- Hark Hoe Tan (ORCID: https://orcid.org/0000-0002-7816-537X)
- Lingzi Lu
- Yi Zhong (ORCID: https://orcid.org/0009-0009-1661-6110)
Institutions
- Sun Yat-sen University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1186/s12964-025-02130-1
- Citations
- 4
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China