Protease-activated receptor-2 (PAR2) mutation attenuates airway fibrosis in mice during the exacerbation of house dust mite‑induced allergic lung disease by multi‑walled carbon nanotubes
Our study demonstrates that PAR2 mediates airway fibrosis but does not influence eosinophilic lung inflammation or mucous cell metaplasia caused by co-exposure to MWCNTs and HDM allergen.
Authors
- Silvio Antoniak (ORCID: https://orcid.org/0000-0001-5523-825X)
- James C. Bonner (ORCID: https://orcid.org/0000-0002-4574-9782)
- Logan J. Tisch
- Ryan D. Bartone
Institutions
- University of North Carolina at Chapel Hill (US)
- North Carolina State University (US)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1186/s12931-025-03168-y
- Citations
- 5
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 8.85
Funders
- National Institute of Environmental Health Sciences