Rumen microbiome associates with postpartum ketosis development in dairy cows: a prospective nested case–control study
Collectively, we found rumen disruption happened after calving among ketosis cows, and insufficient glycogenic substrates, such as propionate, may be related to ketosis development. The study findings have implications for the relationship between rumen microbiome dynamics and host energy metabolism, which lays the foundation for the future rumen microbiome investigation for improving postpartum management in cows. Video Abstract.
Authors
- Hongjian Yang (ORCID: https://orcid.org/0000-0001-5726-5526)
- Shuo Wang (ORCID: https://orcid.org/0000-0003-0225-0612)
- Dongwen Dai (ORCID: https://orcid.org/0000-0003-2252-2662)
- Zhijun Cao (ORCID: https://orcid.org/0000-0002-5519-9462)
- Yanliang Bi (ORCID: https://orcid.org/0000-0001-8183-8208)
- Chen Li (ORCID: https://orcid.org/0000-0001-6110-3714)
- Wei Wang (ORCID: https://orcid.org/0000-0002-9138-9052)
- Shengli Li (ORCID: https://orcid.org/0000-0002-8494-7474)
- Fanlin Kong (ORCID: https://orcid.org/0000-0001-8099-0398)
- Cheng Guo (ORCID: https://orcid.org/0000-0003-3770-0804)
- Yajing Wang (ORCID: https://orcid.org/0000-0003-4744-5106)
- Yijia Zhang (ORCID: https://orcid.org/0009-0003-9490-9345)
Institutions
- Nanjing Agricultural University (CN)
- Xinjiang Agricultural University (CN)
- Ningxia University (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Feed Research Institute (CN)
- State Key Laboratory of Animal Nutrition
- China Agricultural University (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1186/s40168-025-02072-3
- Citations
- 15
- Primary Topic
- Ruminant Nutrition and Digestive Physiology
- Type
- article
- Field-Weighted Citation Impact
- 28.54
Funders
- National Natural Science Foundation of China