High throughput morphological screening identifies chemically defined media for mesenchymal stromal cells that enhances proliferation and supports maintenance of immunomodulatory function

Overall, this highlights how our HTS approach led to the development of CDM formulations for robust MSC expansion and serves as a generalizable tool for improvement of MSC manufacturing processes.

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Publication Details

Journal
Stem Cell Research & Therapy
Published
2025-03-07
DOI
https://doi.org/10.1186/s13287-025-04206-8
Citations
1
Primary Topic
Mesenchymal stem cell research
Type
article
Field-Weighted Citation Impact
1.63

Funders

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article

High throughput morphological screening identifies chemically defined media for mesenchymal stromal cells that enhances proliferation and supports maintenance of immunomodulatory function

Thomas M. Spoerer, Ross A. Marklein, Kanupriya R. Daga, Andrew M. Larey et al.
1 citations
Stem Cell Research & Therapy
Mesenchymal stem cell research
1.63
article

High throughput morphological screening identifies chemically defined media for mesenchymal stromal cells that enhances proliferation and supports maintenance of immunomodulatory function

Thomas M. Spoerer, Ross A. Marklein, Kanupriya R. Daga, Andrew M. Larey, Winifred Asigri
article en
1 citations

Abstract

Overall, this highlights how our HTS approach led to the development of CDM formulations for robust MSC expansion and serves as a generalizable tool for improvement of MSC manufacturing processes.

Stem Cell Research & TherapyVol. 16(1)
Center for Biologics Evaluation and Research (US), United States Food and Drug Administration (US), University of Georgia (US), Georgetown University (US)
National Science Foundation
Openalex Percentile: Top 20%
Mesenchymal stem cell research
1.63
DOIOpen Access PDFOpenAlex
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High throughput morphological screening identifies chemically defined media for mesenchymal stromal cells that enhances proliferation and supports maintenance of immunomodulatory function — Thomas M. Spoerer, Ross A. Marklein, et al. · Stem Cell Research & Therapy (2025) | TGRS Research Map | TGRS