Quercetagetin alleviates inflammatory osteoclastogenesis and collagen antibody-induced arthritis via Nrf2 signaling and Pten/AKT/Nfatc1 axis
Our study presents Quercetagetin 's therapeutic potential in treating RA, outlining its effects and potential mechanisms in suppressing LPS-induced osteoclast activity, and alleviating inflammatory bone destruction in CAIA model, thereby laying the groundwork for further translational research on Quercetagetin and Flos eriocauli in RA treatment.
Authors
- Tao Yuan (ORCID: https://orcid.org/0000-0002-8886-5687)
- Shui Sun (ORCID: https://orcid.org/0000-0002-9744-1595)
- Haojue Wang (ORCID: https://orcid.org/0000-0002-9536-1946)
- Wayne Lee (ORCID: https://orcid.org/0000-0002-0486-360X)
- Dengju Li (ORCID: https://orcid.org/0000-0001-7629-2642)
- Ziqing Li (ORCID: https://orcid.org/0000-0003-3596-3520)
- Jingpeng Wang
Institutions
- Shandong University (CN)
- Chinese University of Hong Kong (HK)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-03-08
- DOI
- https://doi.org/10.1186/s13075-025-03522-x
- Citations
- 3
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China