Anti-proliferation Activity of Some Plant Extracts against MCF-7 and Hdfn Cell Lines

Background: In continuation of the efforts made to find an effective cancer treatment that is relatively safe and with fewer side effects, the current study was developed. Several plants and natural products extracted that are used in folk medicine were used in this study. Methods: The plant extracts were divided into two groups to evaluate their antiproliferation activity against MCF-7 and HdFn cell lines by using an MTT assay. Result: Group A [Saussurea costus, Linum usitatissimum, Teucrium polium, Artemisia annua, Salvia officinalis and Berytephusa cuniclaris (crab)] gave the best results by decreasing the viability of MCF-7 cancer cell line to 42.98% using 400 mg/ml from the extract, well show no high effect on normal cells. Also, the IC50 was calculated for both groups, also group A showed the lower IC50 with 65.22 mg/ml. In conclusion, plant extracts and natural products can be effective anticancer drugs with high safety, further studies will establish to confirm the results.