Brazilin reduces methicillin-resistant Staphylococcus aureus virulence and pathogenicity by decreasing the secretion of the α-hemolysin
These findings reveal, for the first time, BN can alleviate MRSA virulence and pathogenicity by decreasing the secretion of the Hla via inhibiting SaeR. Overall, this study suggests that BN could be a candidate for being submitted to further studies with the aim of its development as a new antibiotic against MRSA.
Authors
- Zhiqiang An (ORCID: https://orcid.org/0000-0001-9309-2335)
- Zhifang Yang (ORCID: https://orcid.org/0000-0003-2008-4443)
- Meng‐Fei Yu (ORCID: https://orcid.org/0000-0003-0937-5012)
- Xiaoxian Zhou
- Zehui Chen (ORCID: https://orcid.org/0000-0003-4055-3008)
- Mingzhe Li (ORCID: https://orcid.org/0009-0004-5332-8453)
Institutions
- Zunyi Medical University (CN)
- Affiliated Hospital of Zunyi Medical College (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1016/j.phymed.2025.156616
- Citations
- 5
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 6.98