Immune checkpoint inhibition in metastatic or non-resectable melanoma after failure of adjuvant anti-PD-1 treatment. A EUMelaReg real-world evidence study
Patients with metastatic melanoma, previously exposed to anti-PD-1 ICI in the adjuvant setting showed significantly lower ORR and shorter PFS to 1L ICI with either Ipi/Nivo or single-agent anti-PD-1 retreatment.
Authors
- Awa A. Gassama
- Jasmina Marić-Brozić (ORCID: https://orcid.org/0000-0002-5978-5960)
- Paweł Teterycz (ORCID: https://orcid.org/0000-0001-7304-714X)
- Ana Arance (ORCID: https://orcid.org/0000-0003-2896-1957)
- Egle Ramelyte (ORCID: https://orcid.org/0000-0001-8262-8608)
- Ralf Gutzmer (ORCID: https://orcid.org/0000-0001-7921-2820)
- Christoffer Gebhardt (ORCID: https://orcid.org/0000-0001-7090-9584)
- John B.A.G. Haanen (ORCID: https://orcid.org/0000-0001-5884-7704)
- Michael Weichenthal (ORCID: https://orcid.org/0000-0002-9060-4961)
- Nethanel Asher (ORCID: https://orcid.org/0000-0002-4094-8045)
- Célèste Lebbé (ORCID: https://orcid.org/0000-0002-5854-7290)
- Shirly Grynberg (ORCID: https://orcid.org/0000-0003-0562-2100)
- Paolo A. Ascierto (ORCID: https://orcid.org/0000-0002-8322-475X)
- Eva Ellebæk (ORCID: https://orcid.org/0000-0001-6748-9232)
- Vanna Chiarion‐Sileni (ORCID: https://orcid.org/0000-0001-9191-9124)
- Dirk Schadendorf (ORCID: https://orcid.org/0000-0003-3524-7858)
- Marc Bender (ORCID: https://orcid.org/0000-0003-2304-1473)
- Christina H. Bruvik Ruhlmann (ORCID: https://orcid.org/0000-0002-3728-273X)
- Friedegund Meier (ORCID: https://orcid.org/0000-0003-4340-9706)
- Charlotte Aaquist Haslund (ORCID: https://orcid.org/0009-0004-6571-2196)
- Caroline Gaudy‐Marqueste (ORCID: https://orcid.org/0000-0001-6955-5117)
- Peter Mohr (ORCID: https://orcid.org/0000-0002-7328-7407)
- Danielle K. DePalo (ORCID: https://orcid.org/0000-0003-2999-0063)
- Elisabeth Livingstone (ORCID: https://orcid.org/0000-0001-8279-9239)
- Iva Gavrilova
- Inge Marie Svane (ORCID: https://orcid.org/0000-0002-9451-6037)
- Wilfried Poudroux (ORCID: https://orcid.org/0000-0003-3313-9087)
- Axel Hausschild
- Enrique Espinosa (ORCID: https://orcid.org/0000-0001-6562-7902)
- Guy Ben‐Betzalel (ORCID: https://orcid.org/0000-0003-3789-4469)
- Fabio Bertoldo (ORCID: https://orcid.org/0000-0003-4564-9332)
- Selma Ugurel (ORCID: https://orcid.org/0000-0002-9384-6704)
- Eva Muñoz‐Couselo (ORCID: https://orcid.org/0000-0001-7556-7608)
- Dimitrios C. Ziogas (ORCID: https://orcid.org/0000-0003-2620-4004)
- Miguel‐Ángel Berciano‐Guerrero (ORCID: https://orcid.org/0000-0002-5437-5196)
- Sylwia Kopeć
- Lidija Kandolf Sekulović (ORCID: https://orcid.org/0000-0002-5221-5068)
- Piotr Rutkowski (ORCID: https://orcid.org/0000-0002-8920-5429)
- Joanna Mangana (ORCID: https://orcid.org/0000-0003-3962-7575)
- Ulrike Leiter (ORCID: https://orcid.org/0000-0002-8019-1577)
- Reinhard Dummer (ORCID: https://orcid.org/0000-0002-2279-6906)
- Helen J Gogas (ORCID: https://orcid.org/0000-0002-0451-2885)
- Caroline Robert (ORCID: https://orcid.org/0000-0002-9493-0238)
- Ronnie Shapira
- Anthonie O. van de Velde
- Gergana Shalamanova (ORCID: https://orcid.org/0009-0006-7569-0829)
- Louise Mahncke-Guldbrandt
- Valerio DelPrete
Institutions
- Hebron University (PS)
- Military Medical Academy (RS)
- Inserm (FR)
- Universität Hamburg (DE)
- National and Kapodistrian University of Athens (GR)
- Université Paris Cité (FR)
- Université Paris-Saclay (FR)
- Dutch Cancer Society (NL)
- Aalborg University Hospital (DK)
- Rabin Medical Center (IL)
- Hospital Universitario La Paz (ES)
- Medical University Plovdiv (BG)
- Odense University Hospital (DK)
- Institut Gustave Roussy (FR)
- Saint Louis University Hospital (US)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
- The Netherlands Cancer Institute (NL)
- Moffitt Cancer Center (US)
- Christian-Albrechts-Universität zu Kiel (DE)
- Assistance Publique – Hôpitaux de Paris (FR)
- University Hospital of Zurich (CH)
- Vall d'Hebron Institut de Recerca (ES)
- University Medical Center Hamburg-Eppendorf (DE)
- Istituto Oncologico Veneto (IT)
- University Hospital Schleswig-Holstein (DE)
- Hospital Clínic de Barcelona (ES)
- Essen University Hospital (DE)
- Sisters of Charity Hospital (HR)
- University Cancer Center Hamburg (DE)
- Vall d'Hebron Hospital Universitari (ES)
- Elbe Kliniken Stade-Buxtehude (DE)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Centre de Recherche en Cancérologie de Marseille (FR)
- Hôpital Saint-Louis (FR)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- University Hospital Carl Gustav Carus (DE)
- Johannes Wesling Klinikum Minden (DE)
- Clinical Research Center Kiel (DE)
- Instituto de Investigación Biomédica de Málaga (ES)
- Technische Universität Dresden (DE)
- University of Tübingen (DE)
- Aalborg University (DK)
- Ruhr University Bochum (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- European Journal of Cancer
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1016/j.ejca.2025.115339
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09