CAT and CXCL8 are crucial cofactors for the progression of nonalcoholic steatohepatitis to hepatocellular carcinoma, the immune infiltration and prognosis of hepatocellular carcinoma
CAT and CXCL8 might impact NASH-HCC progression. HCC patients with low CAT and high CXCL8 expression might have more extensive immune cell infiltration and stronger tumour immune escape. However, probably due to their different effects on CD8 + T cells and reactive oxygen species, increased expression of CAT contributes to improved prognosis in HCC patients, whereas increased expression of CXCL8 leads to a poor prognosis.
Authors
- Guifang Zeng
- Peiping Li (ORCID: https://orcid.org/0000-0003-0861-3111)
- Xialei Liu (ORCID: https://orcid.org/0000-0001-8534-3026)
- Baojia Zou (ORCID: https://orcid.org/0000-0001-8023-3434)
- Jiali Zhao (ORCID: https://orcid.org/0000-0003-2283-2361)
- Yu Li (ORCID: https://orcid.org/0000-0001-8578-7268)
- Jian Li (ORCID: https://orcid.org/0000-0001-7901-5413)
- Zirui Bai
Institutions
- Sun Yat-sen University (CN)
- Fifth Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1007/s12672-025-02051-y
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province