Screening and preclinical assessment of novel Mycobacterium tuberculosis recombinant antigens based tuberculin skin testing
Our results indicate that the E-M recombinant antigen possesses promising characteristics for the detection of tuberculosis infection, demonstrating good safety and efficacy at the preclinical level. Further clinical trials are required to assess its clinical safety, efficacy, and feasibility.
Authors
- Shaojun Pei
- Fei Huang (ORCID: https://orcid.org/0000-0001-8620-3869)
- Richard Anthony (ORCID: https://orcid.org/0000-0002-0550-5273)
- Yang Zhou (ORCID: https://orcid.org/0000-0003-3072-271X)
- Yanlin Zhao (ORCID: https://orcid.org/0000-0002-0278-7543)
- Zhang Guo-qin (ORCID: https://orcid.org/0000-0001-7229-5248)
- Xichao Ou (ORCID: https://orcid.org/0000-0002-3126-4450)
- Yuanyuan Song (ORCID: https://orcid.org/0000-0003-1354-8510)
- Ruida Xing (ORCID: https://orcid.org/0000-0001-9696-0214)
- Shengfen Wang
- Eryong Liu (ORCID: https://orcid.org/0000-0002-5279-2121)
- Hui Xia
- Yang Zheng (ORCID: https://orcid.org/0000-0003-4259-1542)
- Bing Zhao (ORCID: https://orcid.org/0000-0002-1565-685X)
- Lin Zhou
- Minggui Lin
- Faiqa Rashid (ORCID: https://orcid.org/0009-0006-3922-8012)
Institutions
- Chinese Center For Disease Control and Prevention (CN)
- Peking University (CN)
- Capital University of Science and Technology (PK)
- National Institute for Public Health and the Environment (NL)
- Center for Tuberculosis Control of Guangdong Province (CN)
- Beijing Tsinghua Chang Gung Hospital (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1498448
- Citations
- 4
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 5.58