TM4SF1 overexpression in tumor-associated endothelial cells promotes microvascular invasion in hepatocellular carcinoma
TECs with elevated TM4SF1 expression facilitate MVI during HCC via an effect on the EMT, suggesting the potential of TM4SF1 as a therapeutic target.
Authors
- Liangrui Chen
- Chengjun Sui (ORCID: https://orcid.org/0000-0002-3361-9788)
- Zhitao Dong (ORCID: https://orcid.org/0000-0002-6126-7046)
- Junwu Guo
- Binghua Dai (ORCID: https://orcid.org/0000-0003-3139-5749)
- Kecai Duan
- Kunpeng Fang
- Kui Wang (ORCID: https://orcid.org/0000-0003-3503-1563)
- Aijun Li (ORCID: https://orcid.org/0000-0002-0057-4931)
- Keji Chen (ORCID: https://orcid.org/0000-0003-4621-6539)
- Li Geng (ORCID: https://orcid.org/0000-0003-2839-5641)
Institutions
- Second Military Medical University (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-03-07
- DOI
- https://doi.org/10.3389/fonc.2025.1526177
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.94