Can 99mTc-PSMA SPECT/CT Presenting Mirror Image of 68Ga-PSMA PET/CT Be Used for Response Assessment to 177Lu-PSMA in Metastatic Castration-Resistant Prostate Cancer?
A 69-year-old man, with a known case of metastatic castration-resistant prostate cancer (mCRPC) underwent 68 Ga-PSMA PET/CT and 99m Tc-PSMA for evaluation of disease burden and response assessment to 177 Lu-PSMA therapy. 99m Tc-PSMA provided a mirror image of 68 Ga-PSMA. This suggests the potential of 99m Tc-PSMA SPECT/CT for disease evaluation and response assessment to PSMA-based radioligand therapies in advanced-stage mCRPC patients, especially when 68Ga-PSMA PET/CT is not available.
Authors
- Monika Hooda
- Baljinder Singh (ORCID: https://orcid.org/0000-0001-8464-7765)
- Ravimohan Mavuduru
- Sarika Prashar
- Suraj Kumar (ORCID: https://orcid.org/0000-0003-0583-3514)
Institutions
- Post Graduate Institute of Medical Education and Research (IN)
Publication Details
- Journal
- Clinical Nuclear Medicine
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1097/rlu.0000000000005754
- Citations
- 2
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 3.04