Challenges in Diagnosing Parkinson's Disease vs. Multiple System Atrophy: A Case Report Highlighting MRI as a Key Diagnostic Tool

We report a case that outlines the diagnostic challenge faced in differentiating between Parkinson's disease (PD) and multiple system atrophy (MSA) in a 58-year-old man with a history of PD. Despite treatment, the patient exhibited limited response and presented with symptoms suggestive of atypical Parkinsonism, prompting a brain MRI. The MRI revealed characteristic features of MSA, showing putaminal atrophy and altered signal intensity. Differential diagnosis between MSA and PD is crucial, with specific MRI findings serving as key differentiators. Early recognition and differentiation are vital for appropriate management.

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Publication Details

Journal
Nepalese Journal of Radiology
Published
2025-03-07
DOI
https://doi.org/10.3126/njr.v14i2.75737
Primary Topic
Neurological disorders and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Challenges in Diagnosing Parkinson's Disease vs. Multiple System Atrophy: A Case Report Highlighting MRI as a Key Diagnostic Tool

Santosh Maharjan, Girishma Shrestha, Ranjit Kumar Chaudhary, Ashish Lal Shrestha et al.
Nepalese Journal of Radiology
Neurological disorders and treatments
article

Challenges in Diagnosing Parkinson's Disease vs. Multiple System Atrophy: A Case Report Highlighting MRI as a Key Diagnostic Tool

Santosh Maharjan, Girishma Shrestha, Ranjit Kumar Chaudhary, Ashish Lal Shrestha, Rudra Prasad Upadhyaya, Ongden Yonjen Tamang
article en

Abstract

We report a case that outlines the diagnostic challenge faced in differentiating between Parkinson's disease (PD) and multiple system atrophy (MSA) in a 58-year-old man with a history of PD. Despite treatment, the patient exhibited limited response and presented with symptoms suggestive of atypical Parkinsonism, prompting a brain MRI. The MRI revealed characteristic features of MSA, showing putaminal atrophy and altered signal intensity. Differential diagnosis between MSA and PD is crucial, with specific MRI findings serving as key differentiators. Early recognition and differentiation are vital for appropriate management.

Nepalese Journal of RadiologyVol. 14(2)
Beth Israel Deaconess Medical Center (US), Grande International Hospital (NP)
Openalex Percentile: Top 93%
Neurological disorders and treatments
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Challenges in Diagnosing Parkinson's Disease vs. Multiple System Atrophy: A Case Report Highlighting MRI as a Key Diagnostic Tool — Santosh Maharjan, Girishma Shrestha, et al. · Nepalese Journal of Radiology (2025) | TGRS Research Map | TGRS