Iron content of glioblastoma tumours and role of ferrous iron in the hypoxic response in vitro
Elemental and ferrous iron levels were weakly related. Higher ferrous iron content of clinical glioblastoma tissue was associated with longer overall survival compared to lower ferrous iron content, but elemental iron showed no such relationship. Neither form of iron was related to clinicopathological data or markers of 2-OGDD activity. The impact of iron supplementation on the hypoxic response was assessed in three glioblastoma cell lines <i>in vitro</i>, similarly showing only a limited influence of iron on these 2-OGDD enzymes. Our data, together with prior studies in anaemic patients, highlight the importance of healthy iron levels in patients with glioblastoma, but further mechanistic studies are needed to elucidate the molecular pathways involved.
Authors
- Margreet C.M. Vissers (ORCID: https://orcid.org/0000-0003-4261-0854)
- Citra Praditi (ORCID: https://orcid.org/0009-0004-5444-5782)
- Elisabeth Phillips (ORCID: https://orcid.org/0000-0002-9048-367X)
- Gabi U. Dachs (ORCID: https://orcid.org/0000-0003-0017-5129)
- Malcolm Reid (ORCID: https://orcid.org/0000-0002-4129-0214)
- Tania L. Slatter (ORCID: https://orcid.org/0000-0003-4031-0604)
- Janice A. Royds (ORCID: https://orcid.org/0000-0003-1464-2197)
- Eleanor R. Burgess (ORCID: https://orcid.org/0000-0001-9877-5979)
- Rebekah Crake (ORCID: https://orcid.org/0000-0002-0886-2487)
- Eira Beverley-Stone
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Olivia Newton-John Cancer Wellness & Research Centre (AU)
- University of Otago (NZ)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-03-07
- DOI
- https://doi.org/10.3389/fonc.2025.1536549
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94