Synergistic effects of Candida albicans and Porphyromonas gingivalis biofilms on epithelial barrier function in a 3D aspiration pneumonia model
Survival experiments using <i>Galleria mellonella</i> larvae supported these findings, highlighting the reduced survival associated with dual-species biofilms and the potential for high-dose antimicrobial therapies to mitigate this effect. These results emphasize the cooperative mechanisms of <i>C. albicans</i> and <i>P. gingivalis</i> in compromising epithelial barriers and underline the importance of combination therapies targeting both fungal and bacterial components in polymicrobial infections.
Authors
- Marcin Zawrotniak (ORCID: https://orcid.org/0000-0003-4795-7937)
- Dorota Satała (ORCID: https://orcid.org/0000-0002-6233-6680)
- Justyna Karkowska‐Kuleta (ORCID: https://orcid.org/0000-0001-6070-6919)
- Maria Rąpała‐Kozik (ORCID: https://orcid.org/0000-0002-3225-7391)
- Ewelina Wronowska (ORCID: https://orcid.org/0000-0002-2738-832X)
- Aleksandra Brankiewicz (ORCID: https://orcid.org/0000-0002-0065-9142)
- Grażyna Braś (ORCID: https://orcid.org/0000-0002-1814-9263)
- Joanna Kozieł (ORCID: https://orcid.org/0000-0003-3436-6425)
- Ibeth Guevara-Lora (ORCID: https://orcid.org/0000-0002-4802-3434)
- Joanna Budziaszek (ORCID: https://orcid.org/0000-0003-1925-4011)
Institutions
- Jagiellonian University (PL)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-03-07
- DOI
- https://doi.org/10.3389/fcimb.2025.1552395
- Citations
- 3
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 4.40