Isolation, characterization, and genomic analysis of a novel bacteriophage vB_Kp_XP4 targeting hypervirulent and multidrug-resistant Klebsiella pneumoniae
Phage vB_Kp_XP4 exhibits high stability, specificity, potent lytic activity, and no undesirable genes, demonstrating effective in vivo therapeutic efficacy, suggest its potential for clinical applications against <i>Klebsiella pneumoniae</i> infections. The presence of multiple halos during plaque formation further enhances its research value. The complete genome sequence has been submitted to GenBank under accession number PP663283.
Authors
- Junliang Chang
- Bu Wang (ORCID: https://orcid.org/0009-0005-8933-8036)
- Xinya Peng (ORCID: https://orcid.org/0000-0001-9095-5780)
- Shuai Jiao (ORCID: https://orcid.org/0009-0004-7585-2758)
- Changhong Zhang (ORCID: https://orcid.org/0000-0001-6141-474X)
- Hongxia Zhang (ORCID: https://orcid.org/0000-0002-6766-1263)
- Zhihua Zhang (ORCID: https://orcid.org/0009-0002-5298-5078)
- Wei Zhang (ORCID: https://orcid.org/0000-0003-3605-9373)
- Xiaoyu Li (ORCID: https://orcid.org/0009-0008-8894-030X)
- Na Wang (ORCID: https://orcid.org/0000-0001-9177-5749)
- Jun Zhao (ORCID: https://orcid.org/0000-0001-7850-6755)
- Cheng Lv (ORCID: https://orcid.org/0000-0002-0952-0323)
Institutions
- Hebei North University (CN)
- Central Hospital of Zibo (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-03-07
- DOI
- https://doi.org/10.3389/fmicb.2025.1491961
- Citations
- 5
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 8.58