Immune checkpoint inhibitors and cancer-related cognitive decline: a propensity score matched analysis in active chemotherapy patients
Our findings suggest that combining chemotherapy with ICIs may exacerbate CRCD compared to chemotherapy alone. However, reliance on screening tools and self-reported measures limits definitive conclusions. Future studies incorporating comprehensive neuropsychological assessments are warranted. This study underscores the importance of using comprehensive cognitive assessments in future research to better understand the impact of ICIs on cognitive function.
Authors
- Guanqing Zhong
- Nianqi Liu (ORCID: https://orcid.org/0000-0002-5520-1075)
- Yu Si Niu
- Can-Tong Liu (ORCID: https://orcid.org/0000-0001-6479-8793)
- Zong-Qing Zheng
- Jun Lü (ORCID: https://orcid.org/0000-0002-9141-6786)
- Jiling Zeng
- Yifei Ma (ORCID: https://orcid.org/0000-0003-1305-3577)
- Fadian Ding (ORCID: https://orcid.org/0000-0002-9868-3094)
- Jing‐Jer Lin (ORCID: https://orcid.org/0000-0001-8250-7398)
- Pengfei Zhu (ORCID: https://orcid.org/0000-0003-2141-8636)
- Yongluo Jiang (ORCID: https://orcid.org/0000-0002-3456-0570)
- Guangmin Jian
- Xinjia Wang (ORCID: https://orcid.org/0000-0003-1016-4669)
- Yiming Li (ORCID: https://orcid.org/0000-0002-1828-8765)
- Weidong Wang (ORCID: https://orcid.org/0000-0003-2523-3145)
- Ao Zhang (ORCID: https://orcid.org/0000-0003-0045-4777)
- Qi Xin (ORCID: https://orcid.org/0000-0003-3690-598X)
- Tong Huang (ORCID: https://orcid.org/0000-0001-5710-8846)
- Youlong Wang (ORCID: https://orcid.org/0000-0002-0289-7005)
- Weizhi Liu (ORCID: https://orcid.org/0009-0004-5917-212X)
- Z. Chai
Institutions
- Fujian Medical University (CN)
- Sun Yat-sen University (CN)
- Second Military Medical University (CN)
- Capital Medical University (CN)
- Dallas County (US)
- Chinese PLA General Hospital (CN)
- Shantou University (CN)
- Beijing Tian Tan Hospital (CN)
- Cancer Hospital of Shantou University Medical College (CN)
- Jiangxi Maternal and Child Health Hospital (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Second Affiliated Hospital of Shantou University Medical College (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Hainan General Hospital (CN)
- Hainan 301 Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1540442
- Citations
- 2
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 3.04