Neutrophil phenotypes quantify tissue damage caused by major surgery
This is the first study to use fully automated flow cytometry to monitor perioperative changes in neutrophil phenotypes following major surgery. Our findings provide an in-depth readout of the innate immune response and neutrophil activation, highlighting a more pronounced response to pancreatic surgery than to cardiac surgery. Neutrophil phenotyping could serve as a valuable biomarker for patient stratification and management, although larger cohort studies are needed to confirm its predictive value for postoperative complications.
Authors
- Hjalmar C. van Santvoort (ORCID: https://orcid.org/0009-0007-1218-2883)
- Thijs C.D. Rettig (ORCID: https://orcid.org/0000-0001-5634-9672)
- A. Bikker
- Falco Hietbrink (ORCID: https://orcid.org/0000-0003-1462-6840)
- Leo Koenderman (ORCID: https://orcid.org/0000-0002-5636-6453)
- Peter G. Noordzij (ORCID: https://orcid.org/0000-0002-7115-8249)
- Ted Reniers (ORCID: https://orcid.org/0009-0009-4462-5073)
- Nienke Vrisekoop (ORCID: https://orcid.org/0000-0002-7361-1780)
- Emma J. de Fraiture (ORCID: https://orcid.org/0000-0003-4766-566X)
- Nathalie E. W. Vreeman
Institutions
- University Medical Center Utrecht (NL)
- St. Antonius Ziekenhuis (NL)
- Amphia Ziekenhuis (NL)
Publication Details
- Journal
- Frontiers in Surgery
- Published
- 2025-03-07
- DOI
- https://doi.org/10.3389/fsurg.2025.1494831
- Citations
- 3
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.39