Apigenin protects ischemic stroke by regulating intestinal microbiota homeostasis, regulates brain metabolic profile
These findings suggest that apigenin exerts a protective effect on ischemic stroke through the AMPK signaling pathway by modulating intestinal flora and associated metabolites. Consequently, apigenin emerges as a therapeutic candidate warranting further investigation.
Authors
- Hong Ren (ORCID: https://orcid.org/0000-0002-4557-0918)
- Dexi Zhao
- Qiaoli Xu
- Wei He (ORCID: https://orcid.org/0000-0002-4010-1557)
- Xu Wang (ORCID: https://orcid.org/0000-0002-9878-2009)
- Hui Zhang (ORCID: https://orcid.org/0000-0002-7410-6516)
- Yue Wang (ORCID: https://orcid.org/0000-0001-8673-6358)
- Xiaoming Xu (ORCID: https://orcid.org/0000-0002-0602-7955)
- Jinjian Li (ORCID: https://orcid.org/0000-0002-4837-0540)
Institutions
- Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-07
- DOI
- https://doi.org/10.3389/fphar.2025.1553081
- Citations
- 1
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.84