Intratumoral administration of Hibiscus sabdariffa-derived anthocyanins exerts potent antitumor effects in murine cancer models
These findings highlight the potential of <i>H. sabdariffa</i>-derived anthocyanins as adjuvants in cancer therapy. When administered intratumorally, they enhance chemotherapy efficacy and immunogenicity. However, further studies are needed to optimize dosing strategies, evaluate long-term safety, and assess clinical applicability.
Authors
- Nuria Ardaiz (ORCID: https://orcid.org/0000-0002-9168-553X)
- Maritza Roxana García-García (ORCID: https://orcid.org/0000-0002-2996-8264)
- Celia Gomar (ORCID: https://orcid.org/0000-0001-7864-9481)
- Leire Arrizabalaga (ORCID: https://orcid.org/0000-0003-0423-8350)
- Virginia Belsúe (ORCID: https://orcid.org/0000-0002-7939-8415)
- F. Hernández (ORCID: https://orcid.org/0000-0002-4231-1195)
- Noëlia Casares (ORCID: https://orcid.org/0000-0003-3817-6434)
- Pedro Berraondo (ORCID: https://orcid.org/0000-0001-7410-1865)
- Juan Florencio Gómez-Leyva (ORCID: https://orcid.org/0000-0002-3378-1144)
- Fernando Aranda (ORCID: https://orcid.org/0000-0002-9364-474X)
- Aline Risson
- Miriam Ezcurra-Hualde
- David Ruiz-Guillamon
- Román García-Fuentes
- Efren Juarez-Curiel
- Yanelli Jaquelinne Regalado-Noyola
- Silvia Monserrat Rodríguez-Leon
Institutions
- Universidad Autónoma de Guadalajara (MX)
- Secretaría de Salud de Jalisco (MX)
- Tecnológico Nacional de México (MX)
- Navarre Institute of Health Research (ES)
- Clinica Universidad de Navarra (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1549890
- Citations
- 4
- Primary Topic
- Hibiscus Plant Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.23
Funders
- Instituto de Salud Carlos III