A new diphenyl ether with insecticidal activity from the mangrove endophytic fungus <i>Aspergillus</i> sp. GXNU-DY2-12
A new diphenyl ether pseudopithoether C (<b>1</b>), and five known compounds (<b>2-6</b>) were purified from secondary metabolites of the <i>Aspergillus</i> sp. GXNU-DY2-12 cultured in the rice medium. The new structure was analysed by NMR, HR-ESI-MS, and X-ray single crystal diffractometer. Compound <b>1</b> showed potent acetylcholinesterase (AChE) - inhibiting activity and its IC<sub>50</sub> value was 1.02 μM. Notably, it demonstrated remarkable insecticidal efficacy against <i>Diaphorina citri Kuwayama</i>, achieving a mortality rate of 88% under standardised bioassay conditions.
Authors
- Xishan Huang (ORCID: https://orcid.org/0000-0002-3306-4700)
- Meijing Tan
- Youquan Wei
- Wenjun Li (ORCID: https://orcid.org/0000-0003-1152-5016)
- Rui‐Yun Yang
- Weifeng Xu (ORCID: https://orcid.org/0000-0001-6682-3075)
- Shichao Ju
- Fan He
Institutions
- Guangxi Normal University (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1080/14786419.2025.2476201
- Citations
- 2
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- National Natural Science Foundation of China