Association of Conjunctival Cell HLA-DR Expression with the Severity of Signs and Symptoms of Dry Eye Disease at Baseline in the NORTHERN LIGHTS Phase 2 Trial

HLA-DR was present in a wide range of percentages among DED patients indicating the heterogeneous nature of DED. HLA-DR was significantly associated with corneal fluorescein staining suggesting a correlation of the biomarker with ocular surface damage.

Authors

Penny A. Asbell (ORCID: https://orcid.org/0000-0001-7583-7778)
Eric Kuklinski (ORCID: https://orcid.org/0000-0003-0264-2763)
Morten Præstegaard (ORCID: https://orcid.org/0000-0003-2413-791X)
Yi Wei (ORCID: https://orcid.org/0000-0002-2067-6783)
Neeta S. Roy (ORCID: https://orcid.org/0009-0000-7689-7115)

Institutions

Rutgers, The State University of New Jersey (US)
University of Tennessee Health Science Center (US)
Cornell University (US)
MC2 Therapeutics (Denmark) (DK)
Weill Cornell Medicine (US)
Rutgers New Jersey Medical School (US)

Publication Details

Journal: Current Eye Research
Published: 2025-03-07
DOI: https://doi.org/10.1080/02713683.2025.2469254
Primary Topic: Ocular Surface and Contact Lens
Type: article
Field-Weighted Citation Impact: 0.00

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article

Association of Conjunctival Cell HLA-DR Expression with the Severity of Signs and Symptoms of Dry Eye Disease at Baseline in the NORTHERN LIGHTS Phase 2 Trial

Penny A. Asbell, Eric Kuklinski, Morten Præstegaard, Yi Wei et al.

Mar 7, 2025

Current Eye Research

Ocular Surface and Contact Lens

article

Association of Conjunctival Cell HLA-DR Expression with the Severity of Signs and Symptoms of Dry Eye Disease at Baseline in the NORTHERN LIGHTS Phase 2 Trial

Penny A. Asbell, Eric Kuklinski, Morten Præstegaard, Yi Wei, Neeta S. Roy

March 7, 2025article en

Abstract

HLA-DR was present in a wide range of percentages among DED patients indicating the heterogeneous nature of DED. HLA-DR was significantly associated with corneal fluorescein staining suggesting a correlation of the biomarker with ocular surface damage.

Current Eye ResearchVol. 50(6)

Rutgers, The State University of New Jersey (US), University of Tennessee Health Science Center (US), Cornell University (US), MC2 Therapeutics (Denmark) (DK), Weill Cornell Medicine (US), Rutgers New Jersey Medical School (US)

Openalex Percentile: Top 94%

Ocular Surface and Contact Lens

DOI Source OpenAlex

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Association of Conjunctival Cell HLA-DR Expression with the Severity of Signs and Symptoms of Dry Eye Disease at Baseline in the NORTHERN LIGHTS Phase 2 Trial — Penny A. Asbell, Eric Kuklinski, et al. · Current Eye Research (2025) | TGRS Research Map | TGRS