Sodium azide (NaN3) intoxication, “the man who lived”: potential effective antidote and treatment strategy
This case report describes the successful treatment of a suicide attempt involving the ingestion of a supralethal dose of sodium azide (NaN<sub>3</sub>), presenting a prospective novel antidote and therapeutic approach. Treatment encompassed the implementation of high-volume continuous veno-venous hemofiltration (HV-CVVH) alongside the administration of levocarnitine. The latter demonstrated a substantial mitigation of lactate concentration. Comprehensive analyses of serum, ultrafiltrate, and urine revealed the efficacy of HV-CVVH in elimination of NaN<sub>3</sub>. Our case report presents a potential therapeutic approach for managing otherwise fatal NaN<sub>3</sub> intoxications.
Authors
- Erik J. H. Olyslager
- Greetje van der Wal
- Lutea A. A. de Jong (ORCID: https://orcid.org/0000-0002-5158-8794)
- Leo A. J. Kluijtmans (ORCID: https://orcid.org/0000-0002-1999-3378)
- Peter E. Spronk (ORCID: https://orcid.org/0000-0003-3319-8706)
- Jasper X. Geerdink
- Thomas W. van den Goorbergh
Institutions
- Radboud University Nijmegen (NL)
- Gelre Hospitals (NL)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Theological University of Apeldoorn (NL)
Publication Details
- Journal
- Critical Care
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1186/s13054-025-05330-w
- Citations
- 2
- Primary Topic
- Poisoning and overdose treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.51