Postnatal downregulation of Fmr1 in microglia promotes microglial reactivity and causes behavioural alterations in female mice
The downregulation of Fmr1 and its encoded protein FMRP in microglia contributes to behavioural phenotypes in a sex-specific manner.
Authors
- Arkady Khoutorsky (ORCID: https://orcid.org/0000-0003-3846-8728)
- Calvin Wong (ORCID: https://orcid.org/0000-0001-7728-3035)
- Sonali Uttam
- Nahum Sonenberg (ORCID: https://orcid.org/0000-0002-4707-8759)
- Christos G. Gkogkas (ORCID: https://orcid.org/0000-0001-6281-3419)
- Masha Prager‐Khoutorsky (ORCID: https://orcid.org/0000-0001-5388-4602)
- Kevin C. Lister (ORCID: https://orcid.org/0000-0001-7645-3928)
- Volodya Hovhannisyan
- Weihua Cai (ORCID: https://orcid.org/0000-0003-2216-1422)
- Jonathan A. Fan (ORCID: https://orcid.org/0000-0001-9816-9979)
- Mehdi Hooshmandi (ORCID: https://orcid.org/0000-0003-1592-8664)
- David Ho-Tieng
- Nicole Brown (ORCID: https://orcid.org/0000-0001-5302-7360)
Institutions
- McGill University Health Centre (CA)
- McGill University (CA)
- Foundation for Research and Technology Hellas (GR)
Publication Details
- Journal
- Molecular Autism
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1186/s13229-025-00648-2
- Citations
- 6
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.05
Funders
- Canadian Institutes of Health Research