Inhibiting ferroptosis mitigates sheep sperm freezing damage
Both apoptosis and ferroptosis play critical roles in sheep sperm cryopreservation. Fer-1 effectively enhanced cryopreservation outcomes by inhibiting ferroptosis, as evidenced by the restoration of GPX4 expression and improvement in sperm quality indicators. These findings highlight ferroptosis inhibition as a promising strategy for preserving genetic material, with implications for animal breeding and biodiversity conservation.
Authors
- Jian Zhang (ORCID: https://orcid.org/0000-0001-7565-1471)
- Erhan Hai (ORCID: https://orcid.org/0009-0003-0385-1898)
- Jiaxin Zhang (ORCID: https://orcid.org/0000-0002-3315-2858)
- Boyuan Li (ORCID: https://orcid.org/0000-0001-9549-9884)
- Yukun Song (ORCID: https://orcid.org/0000-0001-5827-4598)
Institutions
- Inner Mongolia Agricultural University (CN)
- Inner Mongolia University (CN)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-03-07
- DOI
- https://doi.org/10.3389/fvets.2025.1526474
- Citations
- 8
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 12.15