Stroma AReactive Invasion Front Areas (SARIFA), tumour immune microenvironment, and survival in colorectal cancer
SARIFA status is a highly reproducible, independent prognostic factor in colorectal cancer. SARIFA-positivity is associated with lower densities of antitumourigenic immune cells and the polarisation of macrophages towards a protumourigenic M2-like phenotype.
Authors
- Maarit Ahtiainen (ORCID: https://orcid.org/0000-0002-3263-2307)
- Hanna Elomaa (ORCID: https://orcid.org/0000-0002-5378-7703)
- Ville K. Äijälä (ORCID: https://orcid.org/0009-0005-7664-8027)
- Juha Saarnio (ORCID: https://orcid.org/0000-0002-8443-3625)
- Olli Helminen (ORCID: https://orcid.org/0000-0001-9544-6475)
- Tero Rautio (ORCID: https://orcid.org/0000-0003-4441-9412)
- Jan Böhm (ORCID: https://orcid.org/0000-0001-9664-588X)
- Erkki‐Ville Wirta (ORCID: https://orcid.org/0000-0002-2255-6136)
- Toni T. Seppälä (ORCID: https://orcid.org/0000-0002-4940-3498)
- Meeri Kastinen (ORCID: https://orcid.org/0009-0007-0954-5612)
- Markus J. Mäkinen (ORCID: https://orcid.org/0000-0002-9200-4118)
- Päivi Sirniö (ORCID: https://orcid.org/0000-0002-3988-3782)
- Vesa‐Matti Pohjanen (ORCID: https://orcid.org/0000-0002-4129-4346)
- Jukka‐Pekka Mecklin (ORCID: https://orcid.org/0000-0003-4895-2249)
- Henna Karjalainen (ORCID: https://orcid.org/0009-0008-4694-6703)
- Jukka M. J. Rintala (ORCID: https://orcid.org/0000-0003-1865-8444)
- Juha P. Väyrynen (ORCID: https://orcid.org/0000-0002-8683-2996)
- Anne Tuomisto (ORCID: https://orcid.org/0000-0002-9949-1887)
- Outi Lindgren (ORCID: https://orcid.org/0000-0002-2130-5714)
- Vilja V. Tapiainen (ORCID: https://orcid.org/0009-0003-6306-6525)
- Akseli Kehusmaa (ORCID: https://orcid.org/0009-0004-9415-7283)
- Onni Sirkiä (ORCID: https://orcid.org/0009-0003-8142-7144)
Institutions
- University of Helsinki (FI)
- University of Eastern Finland (FI)
- Oulu University Hospital (FI)
- Helsinki University Hospital (FI)
- Tampere University Hospital (FI)
- Tampere University (FI)
- Central Finland Health Care District (FI)
- University of Jyväskylä (FI)
- University of Oulu (FI)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1038/s41416-025-02972-z
- Citations
- 6
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.78
Funders
- Suomen Lääketieteen Säätiö
- Emil Aaltosen Säätiö
- Oulun Yliopisto
- Sigrid Juséliuksen Säätiö
- Syöpäsäätiö
- Biocenter Finland
- Biocenter, University of Oulu