Epithelial genetic muscarinic receptor 3 ablation induces sex-specific modulation of colonic intestinal progenitor cells and response to intestinal injury
Our data reveal sex differences in the modulation of intestinal, colonic epithelial cells by cholinergic, muscarinic signaling and highlight the potential for therapeutic strategies targeting cholinergic receptor signaling in colonic inflammatory diseases.
Authors
- Katja Steiger (ORCID: https://orcid.org/0000-0002-7269-5433)
- Markus Tschurtschenthaler (ORCID: https://orcid.org/0000-0002-0060-4790)
- Moritz Middelhoff (ORCID: https://orcid.org/0000-0001-8425-3985)
- H. Carlo Maurer (ORCID: https://orcid.org/0000-0002-2193-6014)
- Michael Quante (ORCID: https://orcid.org/0000-0002-8497-582X)
- Klaus‐Peter Janssen (ORCID: https://orcid.org/0000-0002-4707-7887)
- Mohab Ragab
- Timothy C. Wang (ORCID: https://orcid.org/0000-0001-5730-3019)
- Roland M. Schmid (ORCID: https://orcid.org/0000-0002-5751-7313)
- Tatiana Agibalova
- Anastasia Ermolova
- Fabian Heindl
- Jessica Wieland
- A. Hempel
- Caroline Waldherr Ávila de Melo
- Niklas Durner
Institutions
- University of Freiburg (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Columbia University Irving Medical Center (US)
- University Medical Center Freiburg (DE)
- University Hospital Heidelberg (DE)
- TUM Klinikum (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Technical University of Munich (DE)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1093/ecco-jcc/jjaf038
- Citations
- 1
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 2.01