The effect of colchicine on coagulation in patients with chronic coronary disease who use vitamin K antagonists
No significant changes in INR, VKA dosage, or TTR in patients using VKAs after starting or stopping colchicine were observed. These results suggest that there is no need for additional INR monitoring beyond the standard of care when using low-dose colchicine, though further studies in larger populations would help to confirm this conclusion.
Authors
- Michiel Duyvendak
- Aernoud T.L. Fiolet
- Toine C. G. Egberts (ORCID: https://orcid.org/0000-0003-1758-7779)
- Arief Lalmohamed (ORCID: https://orcid.org/0000-0002-3149-3501)
- Arend Mosterd (ORCID: https://orcid.org/0000-0002-6906-2643)
- Jeroen P. A. Houwen (ORCID: https://orcid.org/0000-0001-5521-2519)
- Johan Zwaan
Institutions
- University Medical Center Utrecht (NL)
- St. Antonius Ziekenhuis (NL)
- Pharmo Institute (NL)
- AmbulanceZorg Rotterdam-Rijnmond (NL)
- Meander Medisch Centrum (NL)
Publication Details
- Journal
- European Journal of Clinical Pharmacology
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1007/s00228-025-03815-9
- Citations
- 3
- Primary Topic
- Vitamin K Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.36