Glucocorticoid-mediated acetylated regulation of glucocorticoid receptor and Histone3/Histone4 influence glucocorticoid heterogeneity in children patients with primary nephrotic syndrome
The expression levels of Ac-GR, Ac-H3, and Ac-H4 differed significantly among children's patients with primary nephrotic syndrome (PNS) who manifested distinct GC responses. It is suggested that GC therapy may has a direct impact on the acetylation of GR, H3, and H4.
Authors
- Ping Zeng (ORCID: https://orcid.org/0000-0003-2710-3440)
- Liang Yu (ORCID: https://orcid.org/0000-0002-2020-1446)
- Qianqian Peng (ORCID: https://orcid.org/0000-0002-2018-5706)
- Hongchuan Jin (ORCID: https://orcid.org/0000-0002-6697-3097)
- C. Liang (ORCID: https://orcid.org/0009-0002-3668-0602)
- Feng-Jun Guan (ORCID: https://orcid.org/0000-0002-5622-7111)
Institutions
- Xuzhou Medical College (CN)
- Xuzhou Children Hospital (CN)
Publication Details
- Journal
- The Italian Journal of Pediatrics/Italian journal of pediatrics
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1186/s13052-025-01914-y
- Citations
- 3
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 4.29