Extracellular vesicular delivery of ceramides from pulmonary macrophages to endothelial cells facilitates chronic obstructive pulmonary disease
Our study uncovered a novel mechanism in COPD pathogenesis, where pulmonary macrophages propagate CS-induced metabolic stress to ECs via ceramide-laden EVs, leading to endothelial barrier dysfunction. This intercellular pathway represents a potential target for therapeutic intervention in COPD.
Authors
- Qiqing Huang (ORCID: https://orcid.org/0000-0002-3354-4800)
- Shaoran Shen
- Lili Zhang (ORCID: https://orcid.org/0000-0002-8211-0208)
- Lele Liu (ORCID: https://orcid.org/0000-0002-5980-0761)
- Jianqing Wu (ORCID: https://orcid.org/0000-0002-2537-4821)
- Xiaoli Zou (ORCID: https://orcid.org/0009-0006-6468-9195)
- Tutu Kang
Institutions
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1186/s12964-025-02125-y
- Citations
- 5
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- National Natural Science Foundation of China