Determinants of ascending aortic morphology: cross-sectional deep learning-based analysis on 25 073 non-contrast-enhanced NAKO MRI studies
This study demonstrates the potential of DL and causal analysis for understanding ascending aortic morphology. By disentangling observed correlations using causal analysis, this approach identifies possible causal determinants, such as age, BSA, hypertension, and alcohol consumption. These findings can inform targeted diagnostics and preventive strategies, supporting clinical decision-making for cardiovascular health.
Authors
- Margit Heier (ORCID: https://orcid.org/0000-0002-7317-7566)
- Bernard C Silenou (ORCID: https://orcid.org/0000-0002-4826-0042)
- Stefanie Jaskulski (ORCID: https://orcid.org/0000-0001-5738-3661)
- Berit Lange (ORCID: https://orcid.org/0000-0002-9325-9307)
- Mario Lescan (ORCID: https://orcid.org/0000-0002-3124-4994)
- Henry Völzke (ORCID: https://orcid.org/0000-0001-7003-399X)
- Wolfgang Lieb (ORCID: https://orcid.org/0000-0003-2544-4460)
- Thomas Küstner
- Hansjörg Baurecht (ORCID: https://orcid.org/0000-0002-9265-5594)
- Hans‐Ulrich Kauczor (ORCID: https://orcid.org/0000-0002-6730-9462)
- Kira Trares (ORCID: https://orcid.org/0000-0002-1775-3231)
- Fabian Bamberg (ORCID: https://orcid.org/0000-0002-7460-3942)
- Andreas Wienke (ORCID: https://orcid.org/0000-0001-5871-2586)
- Beate Endemann
- Matthias Bernd Schulze (ORCID: https://orcid.org/0000-0002-0830-5277)
- Tobias Pischon (ORCID: https://orcid.org/0000-0003-1568-767X)
- Louisa Fay (ORCID: https://orcid.org/0009-0005-5071-5519)
- Jeanette Schulz‐Menger (ORCID: https://orcid.org/0000-0003-3100-1092)
- Moritz T. Winkelmann (ORCID: https://orcid.org/0000-0002-3945-3686)
- Nadia Obi (ORCID: https://orcid.org/0000-0002-0903-9142)
- Karin B. Michels (ORCID: https://orcid.org/0000-0001-5137-5505)
- Hermann Brenner (ORCID: https://orcid.org/0000-0002-6129-1572)
- Sergios Gatidis (ORCID: https://orcid.org/0000-0002-6928-4967)
- Thoralf Niendorf (ORCID: https://orcid.org/0000-0001-7584-6527)
- Lilian Krist (ORCID: https://orcid.org/0000-0002-6089-5163)
- Christopher L. Schlett (ORCID: https://orcid.org/0000-0002-1576-1481)
- Bin Yang (ORCID: https://orcid.org/0000-0002-8322-117X)
- Tobias Hepp (ORCID: https://orcid.org/0000-0002-5241-9642)
- Konstantin Nikolaou
- Annette Peters
- Michael Leitzmann
Institutions
- University of Stuttgart (DE)
- Helmholtz Association of German Research Centres (DE)
- Universität Hamburg (DE)
- University of Freiburg (DE)
- Zimmer Biomet (Netherlands) (NL)
- University of Potsdam (DE)
- German Cancer Research Center (DE)
- Max Delbrück Center (DE)
- Heidelberg University (DE)
- Universitätsmedizin Greifswald (DE)
- University Medical Center Freiburg (DE)
- University Hospital Augsburg (DE)
- University Hospital Heidelberg (DE)
- Center for Environmental Health (US)
- Helmholtz Zentrum München (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- Humboldt-Universität zu Berlin (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Helmholtz Centre for Infection Research (DE)
- German Centre for Cardiovascular Research (DE)
- Universitäts-Herzzentrum Freiburg-Bad Krozingen (DE)
- Stanford Medicine (US)
- Helios Hospital Berlin-Buch (DE)
- German Center for Diabetes Research (DE)
- German Institute of Human Nutrition (DE)
- University of Regensburg (DE)
- Martin Luther University Halle-Wittenberg (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- European Heart Journal - Cardiovascular Imaging
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1093/ehjci/jeaf081
- Citations
- 3
- Primary Topic
- Cardiac Imaging and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 4.08