Priming mucosal pathogen-agnostic innate immunity with an intranasal TLR2/6 agonist in an aged population
INNA-051 induced innate immune priming in older individuals and attenuated influenza infection in aged mice. TLR2/6 agonist-mediated responses remain functional in older individuals and this study supports further clinical investigation in aged populations known to be susceptible to viral respiratory infections.
Authors
- Giuseppe D. Ciccotosto (ORCID: https://orcid.org/0000-0003-2512-1047)
- Gary P. Anderson (ORCID: https://orcid.org/0000-0001-6580-3398)
- Robert J.J. O’Donoghue
- Nicholas P. West (ORCID: https://orcid.org/0000-0002-5482-4182)
- Ruth Tal‐Singer (ORCID: https://orcid.org/0000-0002-5275-8062)
- Hayley A. McQuilten (ORCID: https://orcid.org/0000-0002-7089-5300)
- Aowen Zhuang (ORCID: https://orcid.org/0000-0002-7409-6629)
- Andrew Jarnicki (ORCID: https://orcid.org/0000-0002-5088-9536)
- Ping Zhang (ORCID: https://orcid.org/0000-0002-3907-1127)
- Caitlin A. O’Brien (ORCID: https://orcid.org/0000-0001-7290-8366)
- S. M. White (ORCID: https://orcid.org/0000-0002-5123-5307)
- Christophe Demaison
- Francesca Mercuri (ORCID: https://orcid.org/0000-0003-1026-2672)
Institutions
- Griffith University (AU)
- The University of Melbourne (AU)
- Mercu Buana University (ID)
- Respiratory Clinical Trials (AU)
- Melbourne Health (AU)
- RMIT University (AU)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1183/23120541.01044-2024
- Citations
- 1
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- World Health Organization
- National Health and Medical Research Council