Serum immunoglobulin A as a biomarker for respiratory syncytial virus infection in children aged <2 years
This study shows that in children aged <2 years, a previous RSV infection is accompanied by serum pre-F IgA antibody levels above 0.22 AU·mL<sup>-1</sup>, a value close to a previously proposed cut-off (0.19 AU·mL<sup>-1</sup>) based on seroresponse data only. The confirmed threshold can be of use in studies assessing vaccination strategies.
Authors
- Bianca Klee (ORCID: https://orcid.org/0000-0001-5453-7207)
- Cornelia Gottschick (ORCID: https://orcid.org/0000-0002-5822-1055)
- Rutger M. Schepp (ORCID: https://orcid.org/0000-0003-3180-1807)
- Rob van Binnendijk (ORCID: https://orcid.org/0000-0002-5808-1443)
- Charlotte Vernhes (ORCID: https://orcid.org/0009-0007-9915-3232)
- Ryan S. Thwaites (ORCID: https://orcid.org/0000-0003-3052-2793)
- Rafael Mikolajczyk (ORCID: https://orcid.org/0000-0003-1271-7204)
- Annick Moureau (ORCID: https://orcid.org/0000-0002-5306-2833)
- Donghui Zhang (ORCID: https://orcid.org/0000-0001-7258-8577)
Institutions
- Sanofi (France) (FR)
- National Institute for Public Health and the Environment (NL)
- Sanofi (United States) (US)
- Helmholtz Centre for Infection Research (DE)
- Imperial College London (GB)
- Martin Luther University Halle-Wittenberg (DE)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2025-02-27
- DOI
- https://doi.org/10.1183/23120541.01288-2024
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Innovative Medicines Initiative