Cell-intrinsic PD-L1 signaling drives immunosuppression by myeloid-derived suppressor cells through IL-6/Jak/Stat3 in PD-L1-high lung cancer
The tumor-cell-intrinsic function of PD-L1 drives immunosuppression and tumor progression through the PD-L1/Jak/Stat3/IL-6/MDSC axis. This pathway represents a potential therapeutic target to improve ICI efficacy in PD-L1-high NSCLC.
Authors
- Young Keun Chung (ORCID: https://orcid.org/0000-0002-2837-5176)
- Hyein Jeong (ORCID: https://orcid.org/0000-0001-8416-7091)
- Jaemoon Koh (ORCID: https://orcid.org/0000-0002-2824-5080)
- Sehui Kim (ORCID: https://orcid.org/0000-0002-6640-3051)
- Chul‐Hwan Lee (ORCID: https://orcid.org/0000-0003-0643-0100)
- Jeemin Yim (ORCID: https://orcid.org/0000-0002-8571-7486)
- Se‐Hoon Lee (ORCID: https://orcid.org/0000-0002-9219-3350)
- Yoon Kyung Jeon (ORCID: https://orcid.org/0000-0001-8466-9681)
- Seung Geun Song (ORCID: https://orcid.org/0000-0002-1605-2708)
- Hanbyeol Kim (ORCID: https://orcid.org/0000-0001-5149-220X)
- Hyun-Seok Kim (ORCID: https://orcid.org/0000-0003-3767-0350)
- Hye Young Kim (ORCID: https://orcid.org/0000-0001-5978-512X)
- Yingying Li (ORCID: https://orcid.org/0000-0003-1184-9475)
- Soo Hyun Lee (ORCID: https://orcid.org/0000-0001-9665-062X)
- Bhumsuk Keam
- Doo Hyun Chung
Institutions
- Seoul National University (KR)
- Cancer Research Institute (US)
- Korea University Medical Center (KR)
- Samsung Medical Center (KR)
- New Generation University College (ET)
- Seoul National University Hospital (KR)
- SNUH SMG-SNU Boramae Medical Center (KR)
- National University College (PR)
- Korea University (JP)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1136/jitc-2024-010612
- Citations
- 58
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 60.63