Association of body mass index and clinical response in patients receiving ofatumumab for treatment of multiple sclerosis
Inflammatory disease outcomes did not differ but disability progression was more frequent in the highest BMI quartile (BMI >29.2 kg/m<sup>2</sup>). This was associated with lower ofatumumab serum levels. Since body weight itself was not predictive, we assume that body fat composition is critical for ofatumumab effectiveness.
Authors
- Thomas Skripuletz (ORCID: https://orcid.org/0000-0001-8550-335X)
- Christoph Kleinschnitz (ORCID: https://orcid.org/0000-0002-1650-8875)
- Hagen B. Huttner (ORCID: https://orcid.org/0000-0002-0992-8871)
- Pia Winter
- S. Wolff (ORCID: https://orcid.org/0009-0001-1974-1090)
- Refik Pul (ORCID: https://orcid.org/0000-0002-8940-9317)
- Saskia Räuber (ORCID: https://orcid.org/0000-0001-8901-5572)
- Philipp Schwenkenbecher (ORCID: https://orcid.org/0000-0002-1260-1650)
- Tobias Ruck (ORCID: https://orcid.org/0000-0001-6332-8650)
- Steffen Pfeuffer (ORCID: https://orcid.org/0000-0001-5171-4845)
- Alice Willison (ORCID: https://orcid.org/0000-0002-0719-8334)
- Franz Felix Konen (ORCID: https://orcid.org/0000-0002-8609-5674)
- Mark Pawlitzki
- Stefanie Schreiber (ORCID: https://orcid.org/0000-0003-4439-4374)
- Sven G. Meuth
- Ramona Hagler
- Franziska Axhausen
Institutions
- Justus-Liebig-Universität Gießen (DE)
- Medizinische Hochschule Hannover (DE)
- Heinrich Heine University Düsseldorf (DE)
- University of Duisburg-Essen (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2025-03-06
- DOI
- https://doi.org/10.1136/jnnp-2024-335673
- Citations
- 4
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.89