Immunosuppressive microenvironment of liver restrains chemotherapeutic efficacy in triple-negative breast cancer
These findings disclose the compromised chemotherapeutic efficacy in liver tumors of TNBC and elucidate the underlying immune-related mechanisms within the tumor microenvironment. Targeting the specific underpinnings of immune suppression at different tumor sites with selective drugs could optimize chemotherapeutic efficacy.
Authors
- Mengjia Qian (ORCID: https://orcid.org/0000-0002-0610-9985)
- Weiya Zhang (ORCID: https://orcid.org/0000-0003-1142-1460)
- Xiao Wei Sun (ORCID: https://orcid.org/0000-0002-2840-1880)
- Wenbin Zhou (ORCID: https://orcid.org/0000-0003-1220-6797)
- Hong Pan (ORCID: https://orcid.org/0009-0005-7812-3347)
- Pan Zheng (ORCID: https://orcid.org/0000-0003-2598-3544)
- Chang Sun (ORCID: https://orcid.org/0000-0002-2425-9485)
- Xinyu Tang (ORCID: https://orcid.org/0000-0002-4567-4012)
- Qi Qi (ORCID: https://orcid.org/0000-0003-4460-0713)
- Shui Wang (ORCID: https://orcid.org/0000-0002-5687-8715)
- Yue Sun (ORCID: https://orcid.org/0000-0003-0042-1908)
- Muxin Yu
- Wen Sun
- Xinrui Mao
- Peiwen Ling
- Mingduo Liu (ORCID: https://orcid.org/0000-0001-5090-8226)
- Wei Li (ORCID: https://orcid.org/0000-0003-3694-8621)
Institutions
- Regenex Pharmaceuticals (China) (CN)
- Jiangsu Hengrui Medicine (China) (CN)
- Nanjing Jiangning Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1136/jitc-2024-010871
- Citations
- 5
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 5.23
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province