Emergency prevention of tick-borne viral encephalitis in remote regions of the Russian Federation

Tick-borne viral encephalitis (TBE) remains a serious threat to the Russian population, especially in remote regions (Siberian, Ural, Northwestern, Far Eastern districts), where high tick activity is combined with limited access to medical care. The main methods of prevention include vaccination and the use of TBE immunoglobulin and interferon inducers. Vaccination reduces the risk of disease but does not provide complete protection. TBE immunoglobulin is effective only in the first 96 h after tick suction, but its use is limited because of the high cost, complexity of transportation, and low availability in remote areas. Iodophenazone is a proven drug for emergency prevention. Its advantages: it is used both before and after tick suction; the tablet form simplifies use in the absence of medical infrastructure; it is economical (the cost of prevention is lower than for TBE immunoglobulin); reduces the risk of developing severe forms of TBE (odds ratio: 0.162 vs 1.568 without prevention); minimal side effects; and no need for special storage conditions. It is important to inform the public about the proper removal of ticks and the availability of iodophenazone, especially in endemic areas. Iodophenazone is a critically important agent for preventing TBE in remote regions of Russia, combining effectiveness, accessibility, and ease of use. It can reduce morbidity, optimize healthcare costs, and preserve the health of thousands of people.