Effects and mechanisms of breastmilk stem cells in the treatment of white matter injury in newborn rats
Our findings suggest that BSCs can improve the maturation of OLs following WMI in newborn rats. The mechanisms may be attributed to the reduced proinflammatory microglia cells and factors as well as the increased anti-inflammatory microglia cells and factors.
Authors
- Hongju Chen (ORCID: https://orcid.org/0009-0002-0405-7592)
- W. Li (ORCID: https://orcid.org/0009-0006-1204-5929)
- Jun Tang (ORCID: https://orcid.org/0000-0003-4884-4248)
- Maowen Luo
- Dezhi Mu (ORCID: https://orcid.org/0000-0002-2599-7041)
- Yang He (ORCID: https://orcid.org/0000-0002-9241-5101)
- Qiang Chen (ORCID: https://orcid.org/0000-0002-8688-1085)
- Chao Yang (ORCID: https://orcid.org/0000-0002-9114-5824)
- Haoran Wang (ORCID: https://orcid.org/0000-0001-7472-2303)
- Xinyu Zhang (ORCID: https://orcid.org/0000-0003-0921-6898)
- Meng Zhang (ORCID: https://orcid.org/0000-0003-4935-4005)
- Bo Zhang (ORCID: https://orcid.org/0000-0001-8012-0560)
Institutions
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
- Guangzhou Blood Center (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1186/s13287-025-04257-x
- Citations
- 1
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- National Natural Science Foundation of China