Opioidergic modulation of monetary incentive delay fMRI responses
Our results show the primary effects of fentanyl on MID anticipation BOLD in regions associated with the preparation of a motor response to a salient visual cue, rather than in regions typically associated with reward processing such as the striatum. This suggests that opioid agonists do not affect striatal activation during the MID task. Tasks using naturalistic rewards, for example feeding, sex or social contact which induce endogenous opioid signalling, may be more appropriate to probe the effects of fentanyl on reward processing. These results are from male participants' data and therefore may not be generalisable to female participants.
Authors
- Evangelos Zois
- Peter C.T. Hawkins (ORCID: https://orcid.org/0000-0002-2256-1648)
- Mitul A. Mehta (ORCID: https://orcid.org/0000-0003-1152-5323)
- Christopher Muller-Pollard
- Fernando Zelaya (ORCID: https://orcid.org/0000-0002-9525-1560)
- Patricia Conrod (ORCID: https://orcid.org/0000-0002-5570-481X)
- Samuel Turton (ORCID: https://orcid.org/0000-0003-2911-2375)
Institutions
- King's College London (GB)
- Sussex Partnership NHS Foundation Trust (GB)
- IU International University of Applied Sciences (DE)
- Imperial College London (GB)
- Université de Montréal (CA)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1007/s00213-025-06753-7
- Primary Topic
- Neural and Behavioral Psychology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pfizer UK
- Research Trainees Coordinating Centre