Cryptic KMT2A::AFDN Fusion Due to AFDN Insertion into KMT2A in a Patient with Acute Monoblastic Leukemia
This case highlights the importance of integrating multiple testing modalities with expert review when there is a discrepancy. Our findings emphasize the need for a comprehensive approach to genomic assessment to enhance diagnostic accuracy and guide therapeutic decision-making.
Authors
- L. Jeffrey Medeiros (ORCID: https://orcid.org/0000-0001-6577-8006)
- Gökçe Törüner (ORCID: https://orcid.org/0000-0002-5305-6337)
- Keyur P. Patel (ORCID: https://orcid.org/0000-0001-5081-2427)
- Courtney Denton Dinardo (ORCID: https://orcid.org/0000-0001-9003-0390)
- Beenu Thakral (ORCID: https://orcid.org/0000-0001-5140-3633)
- Qing Wei (ORCID: https://orcid.org/0000-0003-0141-9682)
- Guilin Tang (ORCID: https://orcid.org/0000-0002-9482-4806)
- Sanam Loghavi (ORCID: https://orcid.org/0000-0001-8980-3202)
- Rashmi Kanagal‐Shamanna (ORCID: https://orcid.org/0000-0001-7829-5249)
- Ghayas C. Issa (ORCID: https://orcid.org/0000-0002-4339-8683)
- Naveen Pemmaraju (ORCID: https://orcid.org/0000-0002-1670-6513)
- Sa A. Wang (ORCID: https://orcid.org/0000-0001-9385-9911)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
Publication Details
- Journal
- Genes
- Published
- 2025-03-07
- DOI
- https://doi.org/10.3390/genes16030317
- Citations
- 1
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77