Recommendations for management in diagnostics and therapy in herpesviruses infections in children with malignancy or after hematopoietic cell transplantation
Herpesviruses infections are serious complications of therapy in patients after hematopoietic cell transplantation (HCT). Development of infection can demonstrate a life-threatening course, abrogating the effect of previous therapy and contributing to a dismal outcome of underlying disease. Representatives from all the transplant centers belonging to the Polish Society of Pediatric Oncology and Hematology have prepared recommendations for a strategy of diagnostic and therapeutic management of herpesviruses infections in children. This paper presents current recommendations for patients in immune suppression treated in Polish pediatric hematology and HCT centers and is partly based on ECIL 2007–2019 guidelines. It includes detailed guidelines for first- and second-line targeted therapies for CMV, EBV, HSV, VZV, HHV-6, HHV-7 and HHV-8, as well as principles of recommended dosing of antivirals.
Authors
- Anna Pieczonka (ORCID: https://orcid.org/0000-0001-5922-4242)
- Krzysztof Kałwak (ORCID: https://orcid.org/0000-0003-1174-5799)
- Agnieszka Sobkowiak-Sobierajska (ORCID: https://orcid.org/0000-0002-5237-6646)
- Katarzyna Drabko (ORCID: https://orcid.org/0000-0002-7094-9129)
- Pawel Jozef Laguna (ORCID: https://orcid.org/0000-0002-3656-5236)
- Jolanta Goździk (ORCID: https://orcid.org/0000-0002-5449-0266)
- K Czyźewski (ORCID: https://orcid.org/0000-0001-7704-7518)
- Jacek Wachowiak (ORCID: https://orcid.org/0000-0002-4680-603X)
- Katarzyna Derwich (ORCID: https://orcid.org/0000-0001-7239-4035)
- Iwona Malinowska (ORCID: https://orcid.org/0000-0003-0671-7849)
- Jan Styczyński (ORCID: https://orcid.org/0000-0002-3158-119X)
- Maksymilian Deręgowski
Institutions
- Poznan University of Medical Sciences (PL)
- Medical University of Lublin (PL)
- Jagiellonian University (PL)
- Medical University of Warsaw (PL)
- Nicolaus Copernicus University (PL)
- Wroclaw Medical University (PL)
Publication Details
- Journal
- Acta Haematologica Polonica
- Published
- 2025-02-27
- DOI
- https://doi.org/10.5603/ahp.103767
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00