The RNA binding protein CARHSP1 facilitates tumor growth, metastasis and immune escape by enhancing IL-17RA mRNA stabilization in prostate cancer
In conclusion, our results demonstrated that the increased expression of CARHSP1 in PCa is correlated with advanced clinical characteristics and unfavorable prognosis, and CARHSP1 may promote the progression of PCa through enhancing the mRNA stability of IL-17RA and activating its downstream pathways. These results suggest that CARHSP1 is an important regulator of tumor microenvironment in PCa, and CARHSP1-IL-17RA axis could be potential novel therapeutic targets for PCa.
Authors
- Yiguo Jiang (ORCID: https://orcid.org/0000-0002-9499-2594)
- Jianbin Ma (ORCID: https://orcid.org/0000-0001-7426-199X)
- Peng Guo (ORCID: https://orcid.org/0000-0002-4575-8443)
- Kaihua Xue
- Yanan Wang (ORCID: https://orcid.org/0000-0002-0327-0458)
- Shan Xu
- Ke Wang (ORCID: https://orcid.org/0000-0003-1487-190X)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Ministry of Education (TW)
- Shaanxi University of Science and Technology (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1186/s13578-025-01371-4
- Citations
- 2
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China