Prevalence and Antibiogram Pattern of Acinetobacter baumannii from 2013 to 2023 in a Tertiary Care Hospital in the Western Region of Saudi Arabia

<i>Acinetobacter baumannii</i> is pathogen of global concern. It causes infection, especially among immunocompromised individuals in intensive care units, due to its ability to survive for long periods on hard surfaces and under a wide range of environmental conditions and become resistant to almost all the available antibiotics used in clinical practice. <b>Objectives</b>: This study aims to address the gap in <i>A. baumannii</i> surveillance in Saudi Arabia by tracking the prevalence, patterns, and trends of acquired <i>A. baumannii</i> resistance at a healthcare facility in the western part of Saudi Arabia over eleven years. <b>Methods</b>: The study was conducted in a tertiary care hospital in the western region of Saudi Arabia, from January 2013 to December 2023. <b>Results:</b> Our data indicated that <i>A. baumannii</i> infections were predominantly observed in inpatients admitted to the hospital (96%) compared to those treated as outpatients in the emergency clinic (4%). The mean of annual <i>A. baumannii</i> infections isolated from inpatients is 503.3, whereas the mean for outpatients is 21, indicating a statistically significant difference with a <i>p</i>-value of <0.0001. The analysis of the antimicrobial susceptibility profile of <i>A. baumannii</i> demonstrated a variable levels of resistance to the evaluated antibiotics. The lowest resistance rate was for colistin. <b>Conclusions</b>: In conclusion, the incidence patterns of <i>A. baumannii</i> isolates peaked in 2013, then declined, and have recently shown an increase, underscoring the necessity for proactive interventions to curtail its dissemination, notwithstanding initial decreases in infection rates and resistance.