Osteoclast-derived apoptotic bodies accelerate the pathological progression of osteoarthritis via disturbing subchondral bone remodeling
OC-ABs play a critical role in exacerbating OA by promoting subchondral bone remodeling via the RANKL reverse signaling pathway. Rapamycin presents as a promising therapeutic agent capable of mitigating OC-AB-driven pathology, highlighting new avenues for targeted OA treatment.
Authors
- Ziyang Zhang (ORCID: https://orcid.org/0009-0005-6158-7225)
- Ying Qu (ORCID: https://orcid.org/0000-0002-8277-4557)
- Ce Dou (ORCID: https://orcid.org/0000-0002-6983-6354)
- Fei Luo (ORCID: https://orcid.org/0000-0001-6692-1660)
- Yuhang Xi (ORCID: https://orcid.org/0009-0008-5552-7797)
- Jiulin Tan (ORCID: https://orcid.org/0009-0009-2381-2910)
- Hongbo Ai
- Pengbin Yin (ORCID: https://orcid.org/0000-0002-5391-4477)
- Chao Zhang (ORCID: https://orcid.org/0000-0002-8163-9716)
- Jianzhong Xu (ORCID: https://orcid.org/0009-0005-7595-951X)
- Dongyang Zhang (ORCID: https://orcid.org/0000-0001-7152-6120)
- Shuquan Guo
- Yutong Wu (ORCID: https://orcid.org/0000-0002-3659-6892)
Institutions
- Army Medical University (CN)
- Chinese PLA General Hospital (CN)
- 117th Hospital of People's Liberation Army (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Southwest Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.jot.2025.01.004
- Citations
- 7
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 5.64