Lipid metabolic reprogramming drives triglyceride storage and variable sensitivity to FASN inhibition in endocrine-resistant breast cancer cells
Endocrine resistant breast cancer cells undergo a metabolic shift toward increased triglyceride storage and PUFAs with high degrees of desaturation. While TVB-2640 reduced lipid storage in most conditions, it had limited effects on the growth of endocrine resistant breast cancer cells. Targeting specific lipid metabolic dependencies, particularly pathways that produce PUFAs, represents a potential therapeutic strategy in endocrine resistant breast cancer.
Authors
- Duncan Riley (ORCID: https://orcid.org/0000-0003-1829-7116)
- Andrew E. Libby (ORCID: https://orcid.org/0000-0003-3726-2170)
- Michael C. Rudolph (ORCID: https://orcid.org/0000-0002-6147-212X)
- Peter Kabos
- Heather M. Brechbuhl (ORCID: https://orcid.org/0000-0003-3132-4465)
- Carol A. Sartorius (ORCID: https://orcid.org/0000-0002-9170-3988)
- Ashley V. Ward (ORCID: https://orcid.org/0000-0002-8008-7497)
- Rohan Varshney (ORCID: https://orcid.org/0000-0002-8580-3675)
- Jessica Finlay-Schultz (ORCID: https://orcid.org/0000-0002-7855-9870)
- Kaitlyn Hill (ORCID: https://orcid.org/0000-0002-7805-5197)
- Kirsten E. Cosper
Institutions
- University of Oklahoma Health Sciences Center (US)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1186/s13058-025-01991-1
- Citations
- 7
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 6.55
Funders
- Foundation for the National Institutes of Health
- Breast Cancer Research Foundation
- Cancer League of Colorado
- Cancer Center, University of Colorado
- National Cancer Institute