The role of myeloid cell heterogeneity during spontaneous choroidal neovascularization in Vldlr knockout mice
These data suggest that monocytes and monocyte-derived macrophages are dispensable, microglia are likely initiators for CNV development, and choroidal macrophages are potential key contributors to CNV growth and/or maintenance in the Vldlr<sup>-/-</sup> model.
Authors
- Kyle S. Chan (ORCID: https://orcid.org/0000-0003-2855-4913)
- Joseph Strauss (ORCID: https://orcid.org/0000-0003-0474-6267)
- Jeremy A. Lavine (ORCID: https://orcid.org/0000-0002-0884-1336)
- Amrita Rajesh
- Andrew L. Wang (ORCID: https://orcid.org/0000-0003-4016-9460)
- Steven Droho
- Joyce Gong
- Ritvik Viniak
- David Kachar
Institutions
- Northwestern University (US)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1186/s12974-025-03398-3
- Citations
- 3
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.12
Funders
- Research to Prevent Blindness
- BrightFocus Foundation
- National Eye Institute