Cancer-Associated Fibroblasts Serve as Decoys to Suppress NK Cell Anticancer Cytotoxicity in Breast Cancer
Little is known about the influence of CAFs on NK cells in the context of carcinomas. Here, we mechanistically unravel a pathway of CAF-mediated suppression of NK cells in breast cancer, opening possible avenues for new biomarkers and strategies for immune-based therapies. See related commentary by Sherman, p. 1096.
Authors
- Debra Barki (ORCID: https://orcid.org/0000-0002-1770-7104)
- Ofra Golani (ORCID: https://orcid.org/0000-0002-9793-236X)
- Ruth Scherz‐Shouval (ORCID: https://orcid.org/0000-0002-4570-121X)
- Oshrat Levi-Galibov (ORCID: https://orcid.org/0009-0008-7983-4273)
- Shimrit Mayer (ORCID: https://orcid.org/0000-0003-4634-3562)
- Reinat Nevo (ORCID: https://orcid.org/0009-0000-3327-4022)
- Aviad Ben‐Shmuel (ORCID: https://orcid.org/0000-0002-5115-9922)
- Ziv Porat (ORCID: https://orcid.org/0000-0003-3059-181X)
- Coral Halperin (ORCID: https://orcid.org/0000-0001-9987-3888)
- Yaniv Stein (ORCID: https://orcid.org/0000-0002-0331-772X)
- Dana Morzaev‐Sulzbach
- Maya Dadiani (ORCID: https://orcid.org/0000-0002-1561-0755)
- Hallel Rosenberg-Fogler
- Einav Nili Gal‐Yam (ORCID: https://orcid.org/0000-0003-1059-7923)
- Yael Gruper (ORCID: https://orcid.org/0000-0001-7912-2243)
- Gal Yagel (ORCID: https://orcid.org/0000-0002-9518-5989)
- Giulia Carradori
- Mariia Naumova (ORCID: https://orcid.org/0000-0002-2839-1141)
Institutions
- Sheba Medical Center (IL)
- Weizmann Institute of Science (IL)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-0131
- Citations
- 26
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 27.18