Preclinical evaluation of 64Cu-labeled cetuximab in immuno-PET for detecting sentinel lymph node metastasis in epidermal growth factor receptor-positive breast cancer
PET with intravenously administered [<sup>64</sup>Cu]Cu-PCTA-cetuximab demonstrated high precision for diagnosis of SLN metastasis in a xenograft model of EGFR-positive human breast cancer. Although further evaluation is necessary, intradermal/subdermal administration could be a useful therapeutic approach owing to its high accumulation in SLNs.
Authors
- Tomonori Tanei (ORCID: https://orcid.org/0000-0003-2183-8681)
- Masafumi Shimoda (ORCID: https://orcid.org/0000-0002-0832-9877)
- Tadashi Watabe (ORCID: https://orcid.org/0000-0001-8658-2395)
- Yoshiaki Sota (ORCID: https://orcid.org/0000-0001-5963-652X)
- Nanae Masunaga (ORCID: https://orcid.org/0000-0002-6164-5107)
- Tomohiro Miyake (ORCID: https://orcid.org/0000-0002-9362-9822)
- Kaori Abe (ORCID: https://orcid.org/0009-0000-8849-5711)
- Tetsuhiro Yoshinami (ORCID: https://orcid.org/0009-0000-8747-3641)
- Masami Tsukabe (ORCID: https://orcid.org/0009-0009-3284-0833)
- Hiroki Kato (ORCID: https://orcid.org/0000-0003-0838-6772)
- Misato Masuyama (ORCID: https://orcid.org/0009-0008-0873-4486)
- Kenzo Shimazu (ORCID: https://orcid.org/0000-0002-0837-2357)
- Takeshi Usui (ORCID: https://orcid.org/0009-0009-0510-6756)
- Yukie Yoshii (ORCID: https://orcid.org/0000-0002-1773-5957)
- Sadahiro Naka
Institutions
- Osaka University Hospital (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1186/s13058-025-01972-4
- Citations
- 3
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 4.08
Funders
- Japan Society for the Promotion of Science