Layilin regulates Treg motility and suppressive capacity in skin

Regulatory T cells (Tregs) are essential for maintaining immune tolerance in both lymphoid and non-lymphoid tissues. We discovered that layilin, a C-type lectin receptor, is predominantly expressed on Tregs in skin. Layilin was highly expressed on a subset of clonally expanded 'effector' Tregs in both healthy and psoriatic human skin. Layilin-expressing Tregs exhibited a transcriptional profile indicative of enhanced adhesion. Deletion of layilin in Tregs in mice in vivo resulted in significantly attenuated skin inflammation. Mechanistically, layilin enhanced in vitro human Treg adhesion via modulation of lymphocyte function-associated antigen-1, resulting in distinct cytoskeletal alterations consistent with enhanced focal adhesion and lamellipodia formation. Taken together, we define layilin as a critical regulator of Treg-suppressive capacity by modulating motility and adhesion in a non-lymphoid tissue.

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Publication Details

Journal
eLife
Published
2025-03-07
DOI
https://doi.org/10.7554/elife.105277
Citations
3
Primary Topic
Dermatology and Skin Diseases
Type
article
Field-Weighted Citation Impact
6.01
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article

Layilin regulates Treg motility and suppressive capacity in skin

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3 citations
eLife
Dermatology and Skin Diseases
6.01
article

Layilin regulates Treg motility and suppressive capacity in skin

Courtney Macon, Kristen Skruber, Hobart W. Harris, J. W. F. Valle, Michael Rosenblum, Isaac Neuhaus, R. Dyche Mullins, Jarish N. Cohen, Samuel J. Lord, Sean Clancy, Mariela Pauli, Maxime Kinet, Karin Reif, Victoire Gouirand, Margaret M. Lowe, Ali A. Zarrin, Esther Kim, Hong-An Troung
article en
3 citations

Abstract

Regulatory T cells (Tregs) are essential for maintaining immune tolerance in both lymphoid and non-lymphoid tissues. We discovered that layilin, a C-type lectin receptor, is predominantly expressed on Tregs in skin. Layilin was highly expressed on a subset of clonally expanded 'effector' Tregs in both healthy and psoriatic human skin. Layilin-expressing Tregs exhibited a transcriptional profile indicative of enhanced adhesion. Deletion of layilin in Tregs in mice in vivo resulted in significantly attenuated skin inflammation. Mechanistically, layilin enhanced in vitro human Treg adhesion via modulation of lymphocyte function-associated antigen-1, resulting in distinct cytoskeletal alterations consistent with enhanced focal adhesion and lamellipodia formation. Taken together, we define layilin as a critical regulator of Treg-suppressive capacity by modulating motility and adhesion in a non-lymphoid tissue.

eLifeVol. 14
University of California, San Francisco (US), Universidad Católica de Santa Fe (AR), Trex (United States) (US), Universitetshospitalernes Center for Sundhedsfaglig Forskning (DK)
Openalex Percentile: Top 5%
Dermatology and Skin Diseases
6.01
DOIOpen Access PDFOpenAlex
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