ANGEL2 Modulates Wild-type TP53 Translation and Doxorubicin Chemosensitivity in Colon Cancer
Loss of ANGEL2 contributes to decreased WT TP53 translation promoting doxorubicin resistance, which can be rescued via an ANGEL2-derived peptide.
Authors
- Xinbin Chen (ORCID: https://orcid.org/0000-0002-4582-6506)
- Chen S. Suen
- Christopher A. Lucchesi (ORCID: https://orcid.org/0000-0001-8767-7003)
- Jin Zhang (ORCID: https://orcid.org/0000-0002-6835-920X)
- Neelu Batra (ORCID: https://orcid.org/0000-0002-8924-2297)
- P. Ghosh (ORCID: https://orcid.org/0000-0002-7304-2936)
- Saisamkalpa Mantrala
- Darren Tran
- Avani Durve
Institutions
- VA Northern California Health Care System (US)
- University of California, Davis (US)
Publication Details
- Journal
- Molecular Cancer Research
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1158/1541-7786.mcr-24-0702
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00